Allosteric modulator (AgoPAM AP8) bound in groove along the membrane-facing surface of the transmembrane helix bundle of the Free Fatty Acid Receptor FFAR1 a lipid-responsive G-protein coupled receptor also known as GPR40 (PDB:5TZY). Hydrophobic interactions with residues lining the groove stabilize the bulk of the modulator, while the carboxylate moiety at the tip of the modulator is stabilized by interactions with tyrosine residues both in the helical bundle and in the intracellular loop 2 (IL2).

Reference for 5TZY: Lu et al. (2017) Nat Struct Mol Biol 24: 570-577